Intern, Drug Innovation

Seeking an experienced oligonucleotide chemist or pharmaceutical chemist with expertise in design, synthesis, analysis of oligonucleotides. The candidate should have expertise in scientific literature, database and patent search; modern analytical and separation techniques and instrumentation. Successful candidate will work in a multidisciplinary environment involving discovery and development of RNAi chemical modifications, delivery agents and conjugates.

Summary of Key Responsibilities:

• Synthesis of oligonucleotides and conjugates; knowledge in formulation, analysis of drug delivery systems and conjugates for nucleic acids.
• Purification of oligonucleotides using modern separation techniques
• Analysis and characterization using modern analytical techniques (NMR, MS, HPLC, IR, etc.).
• Multitasking and multidisciplinary expertise
• Expertise in scientific data base, literature survey and patent search
• Manuscript Writing skills

Learning Outcomes

1. siRNA synthesis
2. siRNA analytical chemistry and characterization
3. siRNA formulations

Qualifications

• Advanced degree in oligonucleotide chemistry or pharmaceutical chemistry. Graduate or PhD candidates preferred.
• Hands-on experience on separation and analytical instrumentation and scientific database search
• Instrumentation skills, desire to learn bioassays, oligonucleotide synthesis
• Legal authorization to work in the U.S.
• At least 18 years of age prior to scheduled start date

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.