WHY UT SOUTHWESTERN?
With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to U.S. News & World Report, we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you'll discover a culture of teamwork, professionalism, and a rewarding career!
JOB SUMMARY
Plans, coordinates, directs, and participates in work of smaller research project or major unit of large research project in field of specialization for which incumbent is particularly qualified in terms of extensive training and/or experience.
The Corbitt Lab is looking for a Research Scientist to join the translational research team. The lab focuses primarily on the role of genes in pediatric liver disease, namely Biliary Atresia. One of the most interesting things about biliary
atresia is the characteristic rapidly progressive liver fibrosis, which makes this disease the leading indication for pediatric liver transplantation. With a patient-centered focus, the lab aims to model genetic perturbations observed in
patients with cholestatic liver disease to decode the pathophysiology. Using genetically modified mice, the lab models biliary atresia and neonatal liver fibrosis to get to the crux of the disease and molecular pathways that contribute to
disease pathogenesis. The lab has successfully engineered the first genetic model of syndromic biliary atresia in mice by knocking out the gene Pkd1l1. The lab also innovated a new noninvasive diagnostic test for cholestatic
infants on the clinical side. The lab is particularly interested in the role of primary cilia and ciliary genes like Pkd1l1 in pediatric liver disease.
The Research Scientist will support ongoing bench work using transgenic animal models related to biliary atresia and neonatal sclerosing cholangitis and pediatric hepatobiliary tissue. The ideal candidate should be meticulous and have a
strong collaborative approach to research. Hands-on training will be provided for animal surgery and the technical aspect of working with small rodent extrahepatic bile ducts.
Preferred experience includes:
- Experience with animal handling and animal injections.
- Experience with confocal microscopy.
- Experience with tissue sectioning, tissue culture, serum collection, and tissue harvesting.
- Knowledgeable of histological processing, immunofluorescence, confocal imaging, and bulk RNA sequencing.
- Conceptual understanding of workflow for spatial transcriptomics.
- Proficiency with both GraphPad/Prism and Microsoft office for data analysis and creation of publication quality figures.
BENEFITS
UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:
- PPO medical plan, available day one at no cost for full-time employee-only coverage
- 100% coverage for preventive healthcare-no copay
- Paid Time Off, available day one
- Retirement Programs through the Teacher Retirement System of Texas (TRS)
- Paid Parental Leave Benefit
- Wellness programs
- Tuition Reimbursement
- Public Service Loan Forgiveness (PSLF) Qualified Employer
- Learn more about these and other UTSW employee benefits!
EXPERIENCE AND EDUCATION
Required
- Education
PhD with major course work in the field of assignment or
Master's Degree with major course work in the field of assignment or
Bachelor's Degree with major course work in the field of assignment
- Experience
5 years of research experience in the field of assignment with PhD including
2 years at the level of Senior Research Associate or its equivalent or
7 years of research experience in the field of assignment with Master's degree including
3 years at the level of Senior Research Associate or its equivalent or
9 years of research experience in the field of assignment with Bachelor's degree including
4 years Level of Senior Research Associate or its equivalent.
JOB DUTIES
- Plans, organizes coordinates, directs, and personally participates in assigned scientific or medical research project. Selects or assists in selection of key research personnel. Determines specific goals or objectives to be attained. Assigns and reviews work of subordinates. Plans experimental protocols.
- Reviews and analyzes resulting research data. Revises techniques or approaches to work problems as indicated necessary by research data.
- Compiles, writes, and submits research results to supervisor. Prepares or assists in preparation of research papers, reports, and abstracts for publication as one of co-authors.
- Designs, develops, or adapts equipment used in experiments or research to obtain desired results.
- Plans and supervises training of technicians and other laboratory personnel with respect to proper laboratory techniques, use of laboratory equipment, and safety procedures.
- Supervises group of employees of lower grade engaged in performance of technical and professional work, which vary from routine to complex laboratory work tasks.
- May confer with industrial, governmental, or other groups concerning progress or results of research project.
- Performs other duties as assigned.
SECURITY AND EEO STATEMENT
Security
This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.
EEO Statement
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.
University of Texas Southwestern Medical Center
parental leave, paid time off, paid holidays, tuition reimbursement
Feb 18, 2025