Principal Scientist Neurodegeneration

Are you energized by the challenge of shaping and accelerating the scientific expertise of a biology program? If so, this Principal Scientist Neurodegeneration opportunity could be an exciting opportunity to consider.

As Principal Scientist Neurodegeneration in the Translational Unit within RII RU, you will play a critical role in bridging preclinical target and asset validation and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, biofluids, and surgical discard organs.

Despite the listing of GSK-Upper Providence as the primary job location, candidates will be considered equally from the Upper Providence (USA) and Stevenage (UK) sites. This is a lab-based position with an anticipated 4-5 days on-site presence.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following...

• Working closely with other RII RU lines (biology, clinical) and Precision Medicine to design, optimize, and execute preclinical studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples.

• Apply expertise in several of the following capabilities: ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene expression analysis, extracellular vesicle isolation, iPSC cell culture, and emerging technologies.
• Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data.
• Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go to expert on specific technologies and/or disease mechanisms.
• Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments.
• Effectively trouble-shoot assays and, when necessary, develop alternative approaches.
• Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies.
• Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.
• Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.
• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.
• Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.
• Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in a scientific discipline (e.g., Molecular Biology, Genetics, Immunology).
• 4+ years work experience in translational and biomarker development, neurodegeneration and bioinformatics tools for the interpretation of large-scale datasets.
• 6+ years hands-on laboratory experience in several of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), flow cytometry, DNA and RNA sequencing technologies, iPSC cell culture, and emerging technologies.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience in human systems using cell and molecular biology, bioassays, and analytic methods.
• Experience in RII RU relevant disease mechanisms and pathways and the ability to apply this knowledge to translational research and biomarker development.
• Experience with scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, internal reports, technical evidence documents or patents.
• Excellent problem-solving skills and ability to critically analyze scientific data.
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
• Able to independently define strategic approach to tackle specific project or department goals.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
• Experience in the design and execution of biomarker-driven clinical trials and the development of companion diagnostics.
• Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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