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Postdoctoral Fellow - Therapeutic Senescence & Tumor Immunology Laboratory of Paul Romesser, MD

Memorial Sloan
$72,000 to $113,900
United States, New York, New York
200 Hudson Street (Show on map)
Aug 27, 2025

About Us:

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursueour missionat MSK and around the globe.

Role Overview:

Exciting Opportunity at MSK: The Romesser Lab is looking for a Postdoctoral Fellow to join our team studying therapy induced senescence and tumor immunology.

Dr.PaulRomesser's laboratory is recruiting abold and innovativePostdoctoral Fellowtoturn cellular senescence into a weaponized immunologic state against cancer. Rooted in rectal cancer-but engineered to translate across immunerefractory tumors-our program fusesimmunocompetent mouse models, patientderived organoids, singlecell/spatial multiomics, and CRISPRbased functional genomics. You willdrive NIH and foundationfunded projectsthat dissect the senescence-immune interface and fasttrack novel combination therapies toward firstinhuman trials, all within MSK's collaborative, technologyrich ecosystem.

Key Qualifications:

  • PhD or MD/PhDin Cancer Biology, Immunology, Molecular Biology, or a related discipline

  • Hands on expertise in at least one of the following:

    • Immunocompetentmouse tumor models

    • Patientderived organoidculture and manipulation

    • Flow cytometry or advanced immune-profiling platforms

    • Singlecell or spatial omics

  • Computational proficiency-familiarity with R/Python for analysis of bulk, singlecell, or spatialomics data (or a strong willingness to learn).

  • Strong publication recordthat highlights independent thinking and problemsolving.

  • Excellent communication skills(written and oral) and a track record of productive collaboration within interdisciplinary teams.

Core Skills:

  • Experimental Design & Troubleshooting: Ability to conceptualize, execute, and optimize complex invivo (mouse) and exvivo (organoid) studies, including CRISPR perturbations and multiplex assays.

  • SingleCell & Spatial Multiomics: Competence in generating and/or analyzing scRNAseq and spatial transcriptomics data; comfortable using pipelines such as Seurat, Scanpy, or equivalent.

  • Data Analysis & Visualization: Fluency in R/Python for statistics, data integration, and productionquality figures that clearly communicate findings to diverse audiences.

  • Immunological Assays: Proficiency with flow cytometry, ELISA/LEGENDplex, functional Tcell or myeloid assays, and lymphoid and myeloid co-culture assays for dissecting tumor-immune interactions.

  • Scientific Communication & Leadership: Strong track record of manuscript preparation, conference presentations, and collaborative project management; ability to mentor junior trainees and foster an inclusive lab culture.

Application Instruction:

Submit C.V., letter of interest, and references in your application submission to:

Contact Name: Tiara Williamson

Contact Email: WilliT11@mskcc.org

Pay Range: $72,000 to $113,900

Learn more about working as a Post-Doctoral at MSK: Discover MSK's worldclass core facilities, multidisciplinary mentorship, and robust careerdevelopment programs athttps://www.mskcc.org/postdoctoral. As a fellow, you'll leverage cuttingedge technologies-ranging from singlecell and spatialomics platforms to premier animal and organoid cores-while collaborating across oncology, immunology, and computational biology. This uniquely collaborative ecosystem accelerates transformative science into therapies that improve patient outcomes worldwide.

Helpful links:

  • MSK Compensation Philosophy

  • Review Our Great Benefits Offerings

Pay Range: $0.00 - $10,000,000.00 FSLA Status: Exempt

Closing:

At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills.

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

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