Scientist, Targeted LNP Delivery

Overview:

We are seeking a highly motivated, enthusiastic, and innovative scientist to join our LNP group to expand delivery to extra-hepatic tissues of interest. The candidate will innovate and develop LNP delivery solutions suitable for clinical development. The successful candidate will have strong background in nanoparticles with a creative mindset, independent problem-solving ability, collaborative, and desire to enable discoveries at the bench.

This lab-based position is onsite and will be primarily located at 675 W Kendall St, Cambridge, MA 02142.

Key Responsibilities:

• Optimize LNP composition and develop and implement ligand bioconjugation strategies with various ligands.
• Troubleshoot and develop analytical methods to screen LNPs for a desired phenotype.
• Work closely with broader platform teams to develop project plans and coordinate activities.
• Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects to cross-functional teams.
• Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols.

Qualifications:

• Ph.D. in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or related discipline with 1-2 years of industrial or post-doctoral experience with a focus on LNP formulation and delivery systems.
• Direct experience in LNP formulation (in-line mixing or TFF), characterization (DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis, etc.), mRNA and siRNA encapsulation, and bioconjugation is required.
• Experience in targeted LNP or antibody conjugation/post-insertion will be desirable.
• Experience in lipid chemistry and synthesis will be plus.
• Strong team player with excellent verbal and written communication skills.
• Ability to work on multiple projects simultaneously and deliver conclusive results.
• Ability to quickly adapt to new priorities with responsibility in a fast-paced, dynamic, innovative environment.
• Goal oriented, highly organized with significant attention to detail while maintaining highest scientific and ethical standards.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.