Postdoctoral Research Associate I

The Cherrington laboratory focuses on the effect of liver disease on the ability of an individual to metabolize and eliminate drugs and xenobiotics as well as the mechanisms by which drug metabolizing enzymes and transporters are regulated by cellular stress. A major focus of Dr. Cherrington's laboratory has been investigating the mechanisms of altered expression and ability of the major drug metabolizing enzymes and transporters during the progressive stages of nonalcoholic fatty liver disease. They have identified changes in the expression and functionality of several drug metabolizing enzymes in both rodent models and the human disease. They have recently discovered alterations in the expression and localization of key drug transporters in NASH resulting in altered disposition of drugs and xenobiotics.

A major thrust of this work is an effort to identify patients at greater risk of developing adverse drug reactions due to altered pharmacokinetics and overall exposure. This work has led to the development of a non-invasive biomarker in a cohort of pediatric non alcoholic fatty liver disease patients that specifically identifies those with NASH. Dr. Cherrington's laboratory is now posed at the forefront of understanding drug disposition alterations in liver disease.

Outstanding UA benefits include health, dental, vision, and life insurance; paid vacation, sick leave, and holidays; UA/ASU/NAU tuition reduction for the employee and qualified family members; access to UA recreation and cultural activities; and more!

The University of Arizona has been recognized for our innovative work-life programs. For more information about working at the University of Arizona and relocations services, please click here.

The ideal candidate should have a strong passion for science with an ambition to someday become an independent principal investigator running an extramurally funded research program.

Responsibilities include:

• Carry out hypothesis-driven research projects, generate and analyze data, and evaluate progress in multiple inter-related projects.
• Engage in scientific discussion, hypothesis generation, experience design and troubleshooting.
• Work independently.
• Publish in quality academic journals.

Knowledge, Skills and Abilities:

• Ability to be a well organized and hardworking professional.

• PhD in Cellular and Molecular Biology, Endocrinology, Toxicology, Pharmacology, or related field.
• Candidate must show demonstrated ability to prepare, submit and publish articles in academic journals.

• Cellular and molecular biology techniques experience
• Prior working experience in iron homeostasis and kidney cancer research is a plus.